Real world data. Real world results.™

Next generation orthobiologics products

OssDsign is a developer and global provider of next generation orthobiologics products. Based on cutting edge material science, the company develops and markets products that support the body's own healing capabilities, giving patients back the life they deserve.

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OssDsign Catalyst®

OssDsign Catalyst® is a nanosynthetic™, silicate-substituted bone graft designed to upregulate cellular BMP-2, drive dual-pathway healing, including endochondral ossification, and cell-mediated coupled remodeling, enabling rapid, robust fusion in challenging environments.^1,2†*

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Real-world performance starts with real-world patients

The PROPEL Spine Registry is a multi-center, prospective study designed to evaluate Catalyst in everyday clinical practice, including medically complex and high-risk patients.

Capturing outcomes across surgeons, techniques, and patient variability, it reflects how fusion occurs in routine clinical practice.

365 patients have been enrolled to date at 15 sites.

Study details

"My clinical experience with Catalyst is excellent. As the primary investigator in the ongoing clinical trial, receiving interbody fusion clearance reaffirms my choice of Catalyst as the premier bone graft for spine surgery."

Joseph O'Brien, MD

Ortho Bethesda, Bethesda, MD

"Having an interbody indication clearly separates Catalyst from the crowded orthobiologics market."

Peter Whang, MD and Associate Professor

Yale Orthopaedics and Rehabilitation, New Haven, CT

"I choose Catalyst for my patients because of its superior handling, nanotechnology and the interbody indication. This sets it apart in a very crowded synthetic bone graft market."

Fred Mo, MD

Georgetown University Hospital, McLean, VA

"I have been using Catalyst for over a year and am very pleased with its performance for my interbody fusion cases."

K. Brandon Strenge, MD

Strenge Spine Center, Paducah, KY

"Catalyst has excellent handling qualities and mixes well with autograft for lateral gutter bone grafting."

Heeren Makanji, MD

Orthopedic Associates of Hartford, Hartford, CT

"OssDsign Catalyst pushes easily down a funnel and packs the defect well."

Shital Pema, DPM

Orthopedic Associates of Dayton, Dayton, OH

"Catalyst has excellent handling characteristics, especially when packing into interbody cages."

Jesse Eisler, MD

Connecticut Back Center, Vernon, CT

A surgeon must always rely on his or her own professional clinical judgment when deciding whether to use a particular product when treating a particular patient. OssDsign does not dispense medical advice and recommends that surgeons be trained in the use of any particular product before using it in surgery. Please refer to the instructions for use for a full list of indications, contraindications, warnings and precautions.

1. Gibson, I. R., Lopes, V. R., Oliver, R., Wang, T., Wills, D., Buckland, T., & Walsh, W. R. (2025b). Early new bone formation in ovine intramuscular defects: comparison between different silicate-containing calcium phosphate synthetic bone grafts. Journal of Orthopaedic Surgery and Research, 20(1), 369. https://doi.org/10.1186/s13018-025-05740-0

2. Conway, J. C., Oliver, R. A., Wang, T., Wills, D. J., Herbert, J., Buckland, T., Walsh, W. R., & Gibson, I. R. (2021c). The efficacy of a nanosynthetic bone graft substitute as a bone graft extender in rabbit posterolateral fusion. The Spine Journal, 21(11), 1925–1937. https://doi.org/10.1016/j.spinee.2021.05.017

† Results from pre-clinical testing may not be predictive of clinical experience in humans

* Data on file